The objective of this paper is to provide details of the design and response of a full-scale cold-formed steel (CFS)-framed building that was tested under a series of dynamic excitations during different phases of construction. The seismic response of complete buildings framed from CFS is essentially unexplored, although significant work on the behavior of CFS members and subsystems, particularly shear walls has been conducted. The experiments described herein are the first tests of a CFS-framed building designed to North American seismic standards. Seismic testing was conducted using the twin shake tables at the University at Buffalo through the U.S. National Science Foundation Network for Earthquake Engineering Simulation program. The project was conducted in two phases. In the first phase, the building specimen was constructed and tested with only the structural components in place: CFS shear walls sheathed with oriented strand board (OSB), CFS gravity walls (unsheathed), and CFS-framed floor and roof diaphragms sheathed with OSB. Nondestructive testing and design basis earthquake-level testing were performed in this phase. In the second phase, a second building specimen was constructed, to identical specifications as in the first phase. However, the second building specimen was finished with nonstructural components including exterior sheathing of the perimeter gravity walls, gypsum-board sheathing of the interior of the perimeter gravity and shear walls, interior partition walls, ceilings, staircases, and exterior weatherproofing. Nondestructive testing was conducted at construction milestones, and the finished second-phase specimen was destructively tested at the maximum considered earthquake level. This paper presents the fundamental system-level response of these building specimens: period, percent damping, drift, and accelerations. The companion paper details component-level response. Overall, the work demonstrates the excellent performance of these structures under seismic excitation, while highlighting that this performance is related to the full system-level response and not just the designated elements in the lateral-force-resisting system.